Hi Bill,
The second picture of the
Omni San Diego skyline is more impressive. We now have a presence, a feeling that this city is massive, alive and surrounds us. It's color and stature works to capture and hold out attention and gives pleasure to ponder. So first of all I'm impressed and love the image you have shared!
Now some technical questions on your choices in taking the picture. Since you were likely using an excellent lens and a tripod, perhaps with the mirror locked up, you have everything in order for getting the finest image as there will be no blur from movement or the shutter vibration.
Under these conditions, a tiny aperture can degrade all your good work. If you were using a lesser camera, diffraction likely would be a lesser problem.
So why did you choose f22 where you are bound to be risking diffraction limits? It seems to me that you could improved your photograph with an aperture of f 11 or more open.
Asher